on-demand delivery of therapeutics
This research focuses on the precisely timed delivery of therapeutics in response to external triggers. Given that the majority of our applications focus on regenerative medicine, our hydrogel systems are designed to be locally implanted at the treatment site, thereby locally delivering a bioactive agent. For triggers we typically employ ultrasound, but are also exploring magnetic and light stimulation. For therapeutics, we utilize a range of different particles ranging from small molecule drugs, proteins, and nucleic acid-based therapeutics. Most recently, we are employing nanoparticles as these have demonstrated the most precise on/off switch in our system. The developed devices are employed to explore the effects of bioactive cue delivery timing on repair and co-ordination (e.g., diabetic foot ulcers, vascularization).